Substituted acetoacetates are the workhorse intermediates behind Dolutegravir, Bictegravir and a wide family of pyrazole and pyrimidine APIs. We supply the methoxy and chloro series with the consistency antiretroviral manufacturing demands.
Purity and packaging shown are typical trade specifications. Exact specifications are confirmed against your requirement at the quotation stage.
Where each intermediate goes in the finished-product chain — useful when qualifying us as an alternate vendor.
Dolutegravir key intermediate
Also known as: Methyl-4-methoxy acetoacetate, Methyl 4-methoxy-3-oxobutanoate
Upstream chloro intermediate
Also known as: Methyl-4-chloro acetoacetate, Methyl 4-chloro-3-oxobutanoate
β-Ketoester for ring formation
Also known as: Methyl 3-oxopentanoate, Methyl propionylacetate
Send your specification, quantity and delivery location — we respond within one working day.